The Luminesce Alliance brings together an expansive array of cutting edge technologies and state of the art instruments across the partner institutions to provide the best possible scientific support to our researchers and beyond.
Australian Cancer Research Foundation (ACRF) Child Cancer Personalised Medicine Centre @ CCI
This unique precision (personalised) medicine Centre heralds a new era in childhood cancer research and treatment. The Centre houses robotics, libraries of known and clinically-approved drugs, expanded tumour bank facilities, tissue culture and a state-of-the-art laboratory information management system. It also serves as operational headquarters for the Zero Childhood Cancer program, a national initiative of Children’s Cancer Institute and the Kids Cancer Centre at Sydney Children’s Hospital, Randwick.
ACRF Drug Discovery Centre @ CCI and Drug Screening Facility @CMRI
The ACRF Drug Discovery Centre for Childhood Cancer supports Australian drug discovery research, providing the cancer and medical research community with access to advanced technology and expertise in high-throughput chemical small molecule screening. The centre is dedicated to developing new anti-cancer therapeutics, driving research and supporting personalised medicine.
The Drug Discovery Centre houses a sophisticated array of automation equipment including multi-well dispensers, liquid handling robotics, plate reader-based detection systems and a high content screening platform. It comprises over 160,000 small molecules and other boutique compound libraries, using an advanced data management system to integrate biological assay data with chemical compound information. The Drug Screening Facility at CMRI brings together research resources with capacity for high-throughput screening (HTS). The facility offers a range of automated equipment, from liquid-handling to high-content cell imaging/analysis suitable for biochemical and cell-based assays for HTS. The facility supports cancer research groups within the Kids Cancer Alliance (KCA), CMRI, the Westmead Research Hub, as well as collaborative partners nationally and internationally.
The Drug Screening Facility aids research groups and individuals by offering access to equipment and training, instruction in methodology, as well as expertise in the assessment of feasibility and strategy development for projects and programs involving HTS
ACRF International Centre for the Proteome of Cancer (ProCan) @ CMRI
The ProCan facility and international research project was established with a $10 million grant from the Australian Cancer Research Foundation (ACRF) and has received subsequent funding from government and charitable organisations. This world-first initiative was developed by Professors Phil Robinson and Roger Reddel at CMRI.
ProCan is developing a database of information, analysing up to 70,000 samples of all types of cancer from all over the world, to advance scientific discovery and enhance clinical treatment worldwide. This database will mean doctors can more precisely diagnose cancer and effectively narrow down the best type of currently available treatment to target a patient’s individual cancer diagnosis. This is personalised, precision medicine.
Advanced Microscopy brings together the microscopes of ATAC (The ACRF Telomere Analysis Centre), super-resolution, lightsheet and Label-free CARS-capable microscope technologies, and support for light and electron microscopy techniques..
The scientific focus of ATAC is the study of telomeres, the structures at chromosome ends, and their roles in cell proliferation, cancer and ageing, with the secondary focus to support a broad range of medical and biological research projects.
The centre provides access, training and support for a wide range of microscopy techniques
ATAC is located in a purpose-built laboratory and has seven microscope systems available for use by research staff and students, as well as image analysis facilities.
The Australian Paediatric Surveillance Unit (APSU) is a national resource to facilitate active surveillance of uncommon rare childhood diseases, complications of common diseases or adverse effects of treatment.
Bioinformatics is the application of information technology to the study of biology and medicine. It is a multidisciplinary field combining biology, mathematics, statistics and computer science to unravel complex biological problems.
Both teams of data scientists/bioinformatics scientists collaborate with medical researchers to tailor software/computational solutions around specific research questions.
Services offered include assistance with basic bio-statistical questions in the context of bioinformatics work
Biomedical Proteomics and ACRF Centre for Kinomics @ CMRI
Biomedical Proteomics combines applied proteomics with the development of liquid chromatography-mass spectrometry (LC-MS)-based qualitative and quantitative method for protein identification and characterisation.
Biomedical Proteomics offers access to equipment and methodology, the assessment of feasibility and strategy development for project involving MS-based proteomics analysis
The Australian Cancer Research Foundation Centre for Kinomics (ACRF-CFK) – a joint venture between Children’s Medical Research Institute (CMRI) and the University of Newcastle (UoN) – is an Australian-first providing an entirely new approach to the understanding of therapeutic drugs and ways to improve them.
ACRF-CFK brings the research discipline of Kinomics to Australia and a completely novel drug design strategy. It will enable better understanding of current therapies and their unwanted side effects, as well as the development of new drugs for a multitude of human diseases, many of which are currently without any suitable treatment.
BioResources Unit @ CMRI and Transgenic Facility @ Kids Research Westmead
The BioResources Unit at CMRI and The Transgenic Facility at Kids Research provide quality animal care and investigator support through an interactive team approach, working with the investigator, assuring appropriate animal care and use, and compliance with applicable government regulations while advancing the knowledge base of medical science.
The facilities accommodate the use of genetically authenticated small animals and genetically modified rodents for animal experimentation and are fully accredited by the NSW Department of Primary Industries as an animal research establishment.
CellBank Australia provides banking and distribution of cell lines to the research community in Australia and overseas. The facility is open for deposit of cell lines, for provision of services, and for distribution of cell lines from a broad inventory of different species and cell types. Services provided to researchers include Mycoplasma testing, authentication of cell lines by STR profiling, culture of cell lines for expansion and return/distribute to the researcher, and cryo-storage of cell lines in repository.
Cochrane Kidney and Transplant is one of 53 Cochrane Review Groups that are part of Cochrane, an international, independent not-for-profit organisation dedicated to providing up-to-date, accurate information about the effects of health care. Cochrane produces and disseminates systematic reviews of research on healthcare interventions. Its major product is the Cochrane Library.
The Gene and Cell Medicine Facility is a state-of-the-art cell manipulation and gene therapy formulation facility designed to meet the code of Good Manufacturing Practice (cGMP). The Facility’s primary purpose is to provide world class clean rooms for novel and ground-breaking cellular therapies that benefit children. This includes, but is not limited to, gene therapy clinical trials.
Genome and Vector Engineering Core Facility (VGEF) @ CMRI
The VGEF offers range of vectorology-related services, such as consulting in vector system selection, vector design, and cloning. VGEF offers custom packaging of range of viral vectors, including recombinant Adeno-Associated Viral (AAV) vectors, Lentiviral vectors (LV) and Adenoviral (Ad) vectors. In addition to vector-based tools, custom genome-editing services, based on the latest technologies, such as CRISPR/Cas9 and TALEN, in mouse ES cells, human iPS cells, and mouse and human cell lines are also offered.
National Centre for Immunisation Research and Surveillance (NCIRS) @SCHN Westmead
NCIRS is the leading research organisation in Australia that provides objective expert advice on all aspects of vaccine preventable diseases, and other issues related to immunisation, to inform policy and planning for immunisation services in Australia.
The Paediatric Trials Network Australia (PTNA) draws together paediatric researchers from around Australia committed to improving child health through the facilitation of paediatric clinical trials. It is a not for profit, virtual and inclusive network that is open for membership to any paediatric research organisation dedicated to increasing the quality and quantity of paediatric research in Australia
The Rare Diseases Functional Genomics Laboratory (RDFG) aims to empower the diagnosis and treatment of genetic disorders, including the rare and difficult to diagnose and to discover how genetic variants contribute to disease, with the ultimate goal of early curative treatment or disease prevention.
The RDFG laboratory can perform studies such as Western blotting, immunocytochemistry, mRNA analysis and cell-based assays to determine pathogenicity of variants. For genes where the functional studies are beyond the scope of the RDFG laboratory, assistance may be sought from expert researchers, or the Stem Cell & Organoid Facility and related services at CMRI. Your project can be submitted via the submission portal in the Learn more link below. The RDFG team is proudly supported by Luminesce Alliance with the support of NSW Government to coordinate and integrate paediatric research.
The facility supports single cell analysis of genomics, transcriptomics and epigenomics of cell samples from biological specimens, cell lines and experimental materials at the automated high throughput format (10X Genomics system) to automated low-throughput format (Fluidigm C! prep and BioMark system)
Live cell analysis facility offers access to imaging modules including IncuCytes Live Cell Analysis and Cell Voyager High Content Analysis Systems
The Stem Cell & Organoid laboratory provides a variety of services to other researchers which will increase the scope of stem cell research at CMRI and affiliated Institutions. Our goal is to create a broadly available resource of iPS cells, and to generate clinically useful cell type, tissue derivatives and organoids for disease modelling, development of preclinical therapy models and pharmacogenomics / therapeutics screens.
Translational Cancer Research Centre for Kids @ Kids Cancer Alliance)
Kids Cancer Alliance (KCA) is one of seven Cancer Institute NSW Translational Cancer Research Centres incorporating research, clinical training, education and service delivery within a formal framework that links leading research and clinical centres.