• Paediatric Precision Medicine

Paediatric Precision Medicine Computational Biology Program – PPM 2

Project Overview

The Computational Biology Program will integrate and interpret ‘omic (i.e. genomic sequence, protein, metabolite, and microbiome information), biological, and clinical data to accelerate the translation of research findings into a clinical environment and improve patients’ access to new clinical trials, as well as, inform new programs for prevention and earlier diagnosis of disease in the community. This will ultimately lead to more effective treatment strategies for sick children, and their families so that they live longer and better, and reduce the burden on the healthcare system. The predictive models insights will also undoubtedly have utility beyond paediatrics such as adult cancer and other rare disease disciplines. The outcome from this investment will be that children and families in New South Wales will experience world class healthcare improving access to the right treatment at the right time.


  • Children’s Cancer Institute (Australia)
  • Kids Cancer Centre Sydney Children’s Hospital, Randwick, Sydney Children’s Hospitals Network (Australia)
  • Zero Childhood Cancer national and international partners network (8 hospitals, 20 research institutes), including all three NSW Paediatric oncology centres, Peter MacCallum Cancer Centre, Murdoch Children’s Research Institute, Garvan Institute of Medical Research, ProCan Proteomics, Children’s Medical Research Institute (Australia)
  • Children’s Hospital Westmead, Sydney Children’s Hospitals Network (Australia)
  • Children’s Medical Research Institute (Australia)
  • University of NSW (Australia)
  • Sydney University (Australia)

Precision medicine utilises large data sets that combine omics with clinical information and health outcomes to optimize disease diagnosis, treatment and prevention specific to each patient.

Lead Investigators

  • Mark_Cowley@2x

    Associate Professor Mark Cowley

    Group Leader, Computational Biology Group, Children’s Cancer Institute
  • Vanessa_Tyrell@2x

    Vanessa (Ness) Tyrrell

    Co-Head, Personalised Medicine Theme, Children’s Cancer Institute


  • Dr Marie Wong-Erasmus

    Snr Bioinformatics Engineer, Children’s Cancer Institute (Australia)
  • Dr Maely Gauthier

    Snr Bioinformatics Research Officer, Children’s Cancer Institute (Australia)
  • Dr Mark Pinese

    Snr Bioinformatics Research Officer, Children’s Cancer Institute (Australia)
  • Ms Rachel Bowen-Jones

    Children’s Cancer Institute (Australia)
  • Ms Chelsea Mayoh

    Children’s Cancer Institute (Australia)
  • Ms Patricia Sullivan

    Children’s Cancer Institute (Australia)