Precision medicine is at the frontier of modern medical science – but it is expensive and
challenging to introduce into the health system.
While we know it brings health benefits for many children, the long-term costs or effects on the
health system are less clear.
Luminesce Alliance funding has supported research that will contribute to answering these questions.
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We provided a world-first model of the health economic impact of genetic blindness and the benefits to patient and the community that could be achieved by using precision medicine.
Our economic modelling showed the costs of genetic retinal disease across the lifespan and the cost-effectiveness of routine genomic testing, providing important evidence for governments and to inform future approaches.
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Lead Investigators
- Professor Robyn Jamieson, Head, Eye Genetics Research Unit Children’s Medical Research Institute
Research Team
- The GenIMPACT Centre for Economic Impacts of Genomic Medicine
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Children’s Medical Research Institute
The Sydney Children’s Hospital Westmead
Sydney Children’s Hospitals Network
The University of Sydney
Macquarie University
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Economic impact and health implementation analysis of a model for blinding genetic eye conditions
A new pathway to ocular gene therapy | SCHN Kids Research (nsw.gov.au)
Cost of going blind calculated for first time as $5.2m
Publication Blinding Genetic Eye Conditions: Economics and Impacts of Genomics and Precision Medicine
Schofield D, Kraindler J, Tan O, Shrestha R, West S, Ma A, Jelovic D, Grigg J, Jamieson RV. Patient reported health-related quality of life in individuals with inherited retinal diseases. Ophthalmology Science, 2022;2:100106
Schofield D, Kraindler J, Tan O, Shrestha RN, West S, Hart N, Tan L, Ma A, Grigg JR, Jamieson RV. The health care and societal costs of inherited retinal diseases in Australia: a microsimulation modelling study. Medical Journal of Australia. 2023 Jul 17;219(2):70-6.