Luminesce Alliance - Economic Impact and Framework for Precision Therapy - blinding genetic eye conditions Image

Economic Impact and Framework for Precision Therapy - blinding genetic eye conditions

Precision medicine is at the frontier of modern medical science – but it is expensive and
challenging to introduce into the health system.

While we know it brings health benefits for many children, the long-term costs or effects on the
health system are less clear.

Luminesce Alliance funding has supported research that will contribute to answering these questions.

  • We provided a world-first model of the health economic impact of genetic blindness and the benefits to patient and the community that could be achieved by using precision medicine. 

    Our economic modelling showed the costs of genetic retinal disease across the lifespan and the cost-effectiveness of routine genomic testing, providing important evidence for governments and to inform future approaches. 

  • Lead Investigators

    • Professor Robyn Jamieson, Head, Eye Genetics Research Unit Children’s Medical Research Institute 

    Research Team

    • The GenIMPACT Centre for Economic Impacts of Genomic Medicine 
  • Children’s Medical Research Institute 

    The Sydney Children’s Hospital Westmead

    Sydney Children’s Hospitals Network 

    The University of Sydney 

    Macquarie University 

  • Economic impact and health implementation analysis of a model for blinding genetic eye conditions 

    A new pathway to ocular gene therapy | SCHN Kids Research (nsw.gov.au) 

    Cost of going blind calculated for first time as $5.2m  

     Publication Blinding Genetic Eye Conditions: Economics and Impacts of Genomics and Precision Medicine 

     Schofield D, Kraindler J, Tan O, Shrestha R, West S, Ma A, Jelovic D, Grigg J, Jamieson RV. Patient reported health-related quality of life in individuals with inherited retinal diseases. Ophthalmology Science, 2022;2:100106 

    Schofield D, Kraindler J, Tan O, Shrestha RN, West S, Hart N, Tan L, Ma A, Grigg JR, Jamieson RV. The health care and societal costs of inherited retinal diseases in Australia: a microsimulation modelling study. Medical Journal of Australia. 2023 Jul 17;219(2):70-6.