Professor Louis Chesler is a highly regarded clinician researcher dedicated to discovering and translating new treatments for children with cancer. In 2025, he was appointed Executive Director of Children’s Cancer Institute (CCI), following an international career spanning leading hospitals and research institutes in the United States and United Kingdom.

Louis began his career as a paediatric oncologist while establishing a neuroblastoma and medulloblastoma research program at the University of California, San Francisco. Before joining CCI, he led the Paediatric Oncology Experimental Medicine Centre at the Institute of Cancer Research (ICR) in London, recognised for pioneering first-in-child therapeutics and genomics-driven precision medicine trials, including the UK’s national personalised medicine program for childhood cancer, SMPaeds.

He also co-led major cancer modelling initiatives with the MRC National Mouse Genomics Network and served as Head of Translational Cancer Research at The Royal Marsden NHS Foundation Trust. Louis has a strong interest in clinical genomics, liquid biopsy and immune-oncology, with a focus on advancing laboratory discoveries into transformative therapies for children with cancer.