Prof. Louis Chesler is an internationally, highly regarded clinician researcher who has committed his life’s work to discovering new treatments and translating them into clinical practice for children with cancer.

He is a Professor of Childhood Cancer Biology and Therapeutics; Executive Director, Children’s Cancer Institute of Australia; and Co-Director, The Minderoo Comprehensive Children’s Cancer Centre, Sydney Children’s Hospital, Randwick.

Prof. Chesler began his career as a paediatric oncology consultant while leading a major neuroblastoma and medulloblastoma research program at UCSF, focusing early on the oncogene MYCN, a driver of high‑risk childhood cancer.

A Fellow of the Royal College of Paediatrics and Child Health (UK), he has spent nearly two decades directing the Paediatric Oncology Experimental Medicine (POEM) Centre at the Institute of Cancer Research (ICR) in London. The Centre is internationally recognised for first‑in‑child therapeutics and advancing genomics‑driven precision medicine, including the UK’s national personalised paediatric cancer program, SM Paeds.

Alongside leading POEM, Prof. Chesler heads the ICR’s Paediatric Cancer Modelling and Preclinical Therapeutics group and the Cancer Modelling Programme of the MRC National Mouse Genomics Network. His work spans immuno‑oncology and novel CAR T‑cell therapies progressing toward clinical trials through global collaborations. He is also a Research Group Leader at the ICR and a practising physician at The Royal Marsden, focusing on hard‑to‑treat childhood cancers.

Renowned for securing major programmatic funding, he drives basic, translational and clinical research that bridges laboratory discovery with real‑world advances in childhood cancer care.