Computational Biology Data Program
We brought together the largest computational biology team in paediatrics in Australia to launch a platform for computational analysis and interpretation of data, underpinning precision medicine in our hospitals.
The team brings together data from the genome and other biological measurements and compares these data to healthy children and other children who have had similar cancers before. Using a database of patients who have had this type of cancer previously, the software then identifies the genetic changes most likely to be implicated in the cancer — and what the best treatment approach is likely to be.
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We identified new genes and markers of childhood cancer risk, and translated these to improve diagnosis and treatment outcomes for children.
Our technologies and close partnership with clinicians meant we identified the genetic basis of cancer in more than 90% of cases.
The creation of Australia’s largest computational biology group solely focused on paediatric cancer has allowed the further ability to analyse precision medicine data at national-scale for every Australian child with cancer.
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Lead Investigators
- A/Professor Mark Cowley
Head, Computational Biology Group, Children’s Cancer Institute - A/Professor Vanessa Tyrrell
Program Leader, Zero Childhood Cancer Co-Head of Theme, Personalised Medicine, Children’s Cancer Institute
Research Team
- Dr Marie Wong-Erasmus, Precision Medicine Informatics Manager, Children’s Cancer Institute (Australia)
- Dr Mark Pinese, Snr Bioinformatics Research Officer, Children’s Cancer Institute (Australia)
- Mustafa Syed, Senior Bioinformatics Engineer, Children’s Cancer Institute (Australia)
- Chelsea Mayoh, PhD student, Children’s Cancer Institute (Australia)
- Patricia Sullivan, PhD student, Children’s Cancer Institute (Australia)
- A/Professor Mark Cowley
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- Children’s Cancer Institute (Australia)
- Children’s Medical Research Institute (Australia)
- Children’s Hospital at Westmead, Sydney Children’s Hospitals Network (Australia)
- University of Sydney (Australia)
- UNSW Sydney (Australia)
- Kids Cancer Centre Sydney Childrens Hospital, Randwick, Sydney Childrens Hospitals Network
- Zero Childhood Cancer national and international partners network (8 hospitals, 20 research institutes), incl. all three NSW Paediatric oncology centres, Peter MacCallum Cancer Centre, Murdoch Children’s Research Institute, Garvan Institute of Medical Research, ProCan Proteomics (CMRI),
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See Luminesce Alliance Publications – completed research – Computational Biology Data Program